I will talk about three recent developments in quantum information that I think will leave a long-term legacy on science in general. The first is centered on quantum simulations of complex physical systems. The second is regarding the role of quantum coherence in living systems. The third is our emerging, information-based, understanding of the quantum nature of reality. The importance of each of these directions goes well beyond the narrowly defined goal of making faster algorithms, though that goal itself is also worth pursuing. I will speak about concrete open problems within each of these three areas and review some of the key recent findings.